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Esketamine Nasal Spray (ESKETAMINE NASAL - SPRAY)

For depression.

Brand Name(s): Spravato

Generic Name: Esketamine

Instructions

Keep the medicine at room temperature. Avoid heat and direct light.

This medicine is for use in the nose. Avoid getting the medicine into the eyes or mouth. Rinse the eyes with water if the medicine is sprayed into the eyes.

Ask your doctor, nurse or pharmacist to show you how to use this medicine correctly.

Do not eat for at least 2 hours before using this medicine.

Do not drink any liquids for at least 30 minutes before using this medicine.

Blow and wipe your nose with a clean tissue before using this product.

Do not spray the medicine directly on the middle wall of your nose (nasal septum).

Do not blow nose for at least 5 minutes after using this medicine.

You must be monitored by a healthcare professional for at least 2 hours after each dose is given.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

This medicine can be habit-forming. If you use this medicine regularly for a long time, it can lead to withdrawal symptoms when you stop. Please use this medicine only as directed.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Do not use the medication any more than instructed.

If possible, avoid using with marijuana or other medicines that can cause dizziness or drowsiness. These include allergy/cold products, muscle relaxers, sleep aids, and pain relievers.

Be very careful not to spray the medicine into your eyes. Wash your hands thoroughly before touching your eyes.

The effects of this medicine can last for hours after you use it. Do not drive, operate machinery, or do anything else that requires alertness until the day after a good night's rest and until you are able to do so safely.

Please check with your doctor before drinking alcohol while on this medicine.

Family should check on the patient often. Call the doctor if patient becomes more depressed, has thoughts of suicide, or shows changes in behavior.

Call the doctor if there are any signs of confusion or unusual changes in behavior.

Do not breastfeed while on this medicine. This medicine can pass through breast milk to the baby.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Some patients have serious side effects from this medicine. Ask your pharmacist to show you the information from the Food and Drug Administration (FDA) and discuss it with you.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • dizziness or drowsiness
  • lack of energy and tiredness
  • high blood pressure
  • irritation inside the nose
  • nausea

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • shallow, irregular breathing
  • chest pain
  • changes in memory, mood, or thinking
  • fainting
  • feeling disconnected from yourself, your thoughts, feelings, space, and time
  • severe or persistent headache
  • restlessness
  • seizures
  • shortness of breath
  • suicidal thoughts
  • increased urinary frequency
  • difficulty or discomfort urinating
  • waking up at night to urinate
  • blurring or changes of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.