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patisiran

Pronunciation: PAT i SIR an

Brand: Onpattro

What is the most important information I should know about patisiran?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is patisiran?

Patisiran works by decreasing a protein called transthyretin (TTR, made primarily in the liver). Hereditary transthyretin- mediated amyloidosis (hATTR) is a rare condition in which abnormal deposits of TTR protein build up in many parts of the body, interfering with normal function.

Patisiran is used to treat polyneuropathy (damage of multiple nerves throughout the body) in adults with hATTR. This medicine can help reduce symptoms such as pain, numbness, tingling, abnormal heartbeats, diarrhea, constipation, weakness, and problems with movement in your arms or legs.

Patisiran may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using patisiran?

You should not use patisiran if you are allergic to it.

Before using patisiran tell your doctor about all your medical conditions or allergies.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How is patisiran given?

Patisiran is given as an infusion into a vein. A healthcare provider will give you this injection once every 3 weeks.

This medicine must be given slowly, and the infusion can take about 80 minutes to complete.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when patisiran is injected.

You may be given other medications to help prevent serious side effects or an infusion reaction.

Your doctor may have you take extra vitamin A while you are using patisiran. Take only the amount of vitamin A your doctor has prescribed. An overdose of vitamin A can cause vision problems or other serious side effects.

Call your doctor at once if you have vision problems (especially at night) while you are taking vitamin A.

Patisiran doses are based on weight. Your dose needs may change if you gain or lose weight.

You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. You may also need frequent eye exams.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your patisiran injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while using patisiran?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of patisiran?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver if you feel warm, dizzy, nauseated, light-headed, or have a headache, stomach pain, chest pain, or trouble breathing.

Common side effects may include:

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect patisiran?

Other drugs may affect patisiran, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about patisiran.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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