Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.

pegloticase

Pronunciation: peg LOE ti kase

Brand: Krystexxa

What is the most important information I should know about pegloticase?

You should not receive pegloticase if you are allergic to it, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Tell your caregivers right away if you feel itchy, light-headed, short of breath, or have chest discomfort or skin redness during the injection.

What is pegloticase?

Pegloticase is an enzyme that metabolizes uric acid into a harmless chemical that is eliminated from the body in urine.

Pegloticase is used to treat chronic gout. Pegloticase is usually given after other gout medications have been tried without successful treatment of symptoms.

Pegloticase may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking pegloticase?

You should not be treated with pegloticase if you are allergic to it, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Some medicines can cause unwanted or dangerous effects when used with pegloticase. Your doctor may change your treatment plan if you also use:

  • allopurinol (Zyloprim); or
  • febuxostat (Uloric).

Tell your doctor if you have ever had:

  • heart problems; or
  • high blood pressure.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I take pegloticase?

Pegloticase is given as an infusion into a vein, usually once every 2 weeks. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take at least 2 hours to complete.

You may be given other medications to help prevent serious side effects or an allergic reaction. Your doctor may also recommend other gout medications to use during the first 6 months of treatment with pegloticase. Keep using all medicines for as long as your doctor has prescribed.

When you first start using pegloticase, you may have an increase in gout flares.

Your doctor will need to check your progress on a regular basis.

Tell your doctor if your symptoms do not improve after 3 months of treatment.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your pegloticase injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking pegloticase?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of pegloticase?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver if you feel nervous, light-headed, itchy, short of breath, or have fast heartbeats, chest discomfort, or redness of your skin during the injection.

Call your doctor at once if you have:

  • chest pain; or
  • flushing (warmth, redness, or tingly feeling).

Common side effects may include:

  • allergic reactions;
  • new gout flares;
  • vomiting, constipation;
  • bruising; or
  • sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pegloticase?

Other drugs may affect pegloticase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about pegloticase.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 3.01. Revision date: 8/9/2018.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.