Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.


Pronunciation: ez ET i mibe

Brand: Zetia


slide 1 of 3, Zetia,

10 mg, oval, white, imprinted with 414

Image of Zetia
slide 1 of 3


slide 2 of 3, Ezetimibe,

10 mg, capsule, white, imprinted with 773

Image of Ezetimibe
slide 2 of 3


slide 3 of 3, Zetia,

10 mg, oval, white, imprinted with 414

Image of Zetia
slide 3 of 3

What is the most important information I should know about ezetimibe?

Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine.

What is ezetimibe?

Ezetimibe is used to treat high cholesterol.

Ezetimibe is sometimes given together with other cholesterol-lowering medications.

Ezetimibe may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ezetimibe?

You should not use ezetimibe if you are allergic to it, or if you have:

  • moderate to severe liver disease.

Not approved for use by anyone younger than 10 years old.

You should not use ezetimibe with a "statin" cholesterol medicine (Zocor, Lipitor, Crestor, and others) if:

  • you have active liver disease;
  • you are pregnant; or
  • you are breastfeeding a baby.

Statin cholesterol medications can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

Tell your doctor if you have ever had:

  • liver disease;
  • kidney disease; or
  • unexplained muscle pain or weakness.

Tell your doctor if you are pregnant or breastfeeding.

Use effective birth control to prevent pregnancy while you are using ezetimibe with a statin medicine. Tell your doctor if you plan to become pregnant.

Do not breastfeed if you take ezetimibe with a statin medicine.

How should I take ezetimibe?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Ezetimibe is usually taken once daily at the same time each day.

You may take ezetimibe with or without food.

Ezetimibe may be taken at the same time with fenofibrate, or with a statin medication such as atorvastatin, lovastatin, simvastatin, pravastatin, or fluvastatin.

Your treatment may also include diet, exercise, weight control, and blood tests.

You may need frequent medical tests, even if you have no symptoms.

Your cholesterol levels may not improve for up to 2 weeks.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking ezetimibe?

Avoid eating foods high in fat or cholesterol, or ezetimibe will not be as effective.

What are the possible side effects of ezetimibe?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Ezetimibe can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine.

Side effects may be more likely in older adults.

Common side effects may include:

  • diarrhea;
  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • pain in an arm or leg;
  • joint pain; or
  • muscle pain while taking ezetimibe with a statin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ezetimibe?

If you also take other cholesterol medication: Take ezetimibe 2 hours before or 4 hours after taking cholestyramine, colestipol, or colesevelam.

Tell your doctor about all your other medicines, especially:

  • cyclosporine;
  • fenofibric acid;
  • gemfibrozil; or
  • a blood thinner --warfarin, Coumadin, Jantoven.

This list is not complete. Other drugs may affect ezetimibe, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about ezetimibe.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2022 Cerner Multum, Inc. Version: 7.01. Revision date: 7/6/2021.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.